The heart of Reina Sofia, this 18th-century structure was originally a hospital designed by José de Hermosilla and Francisco Sabatini. Now, it houses the museum’s permanent collection, featuring 20th-century Spanish masterpieces, including Picasso’s iconic Guernica, Dalí’s The Great Masturbator, and Miró’s Girl at the Window. The building also includes a central courtyard and an outdoor sculpture garden.